C W and pulse Doppler diagnostic system

ABSTRACT

In an interlaced pulse-echo and range-gated Doppler system, an ultrasound transmitter generates a train of constant repetition rate echo pulse interlaced with a Doppler pulse train of plural bursts. The time duration between each burst and the preceding range gate opening is held constant while the time to the successive range gate opening is automatically varied to provide a continuously variable PRF tracking of the console range gate depth setting. The power of the transmitted signal is internally varied in the same sense and the cutoff frequency of the receiver low pass tracking filters is varied in the opposite sense to optimize signal-to-noise ratio at various tissue inspection depths. Selectable turnable high pass filters normalized to low velocity roll-off eliminate artifact for peripheral or central vascular probes. The detection system operates in quadrature and includes a synchronous demodulator and a peak detector, and a level detector operative on peak detected signals. Transducer probes interchangeably usable in the system include within each probe a narrow band amplifier critically turned to the respective probe crystal to provide further S/N ratio improvement. The system is operable in CW or pulsed Doppler modes dependent on switch setting on the split crystal probe.

BACKGROUND OF THE INVENTION

This invention relates to pulse Doppler diagnostic systems, and is moreparticularly directed to improvements in such systems enabling increasedaccuracy, facility of use, signal-to-noise ratio, and adaptability todifferent modes of operation of such systems. While the followingdisclosure is directed specifically to the use of the invention inmedical applications such as monitoring blood flow, it will be apparentthat the concepts of the invention are adaptable for other applications,and it is intended herein that the scope of the invention include suchother applications.

In the past, medical systems have been provided that employ pulseDoppler ultrasound for non-invasive cardiac diagnosis, such asmonitoring of blood flow in vessels and arteries and determiningpulmonary arterial pressure or hypertension. Such systems employ echo,continuous wave or pulse Doppler ultrasound signals. Such systems aredisclosed, for example, in U.S. Pat. No. 4,058,001, Waxman, U.S. Pat.No. 4,137,777, Haverl, U.S. Pat. No. 4,205,555, Hashiguichi, U.S. Pat.No. 4,242,911, Martin, U.S. Pat. No. 4,103,679, Aronson, U.S. Pat. No.4,141,347, Green et al., U.S. Pat. No. 3,802,253, Lee, U.S. Pat. No.4,097,835, Green, U.S. Pat. No. 4,313,444, Glenn, U.S. Pat. No.4,318,413, Iinuma, U.S. Pat. No. 4,387,720, Miller, U.S. Pat. No.4,390,025, Takemura, et al, U.S. Pat. No. 4,398,540, Takemura et al andU.S. Pat. No. 4,407,293, Suarez, Jr., et al.

Using the Doppler principle, pulse and continuous wave ultrasound arepresently being used in medicine to make non invasive measurements ofperipheral and central cardiovascular blood flow velocities. Otherultrasound measurements such as cardiac valve movement velocities, valvetime intervals, and contractual and relaxation periods of the cardiacchambers provide useful diagnostic information in the assessment ofcardiovascular disease. The velocity measurements are made by processingthe returned "echo" signals for a change in frequency. ThisDoppler-shifted frequency, which is directly related to the velocity ofthe reflector, is usually in the audible range and contains usefuldiagnostic information simply by listening. However, if the velocity andits direction are to be known and recorded, further electricalprocessing is necessary.

Flow velocity and direction information can be obtained by comparing thereceived signal frequency with the transmitted frequency and thetransmitted frequency shifted 90 degrees in phase. Using tis technique,two Doppler shift signals are obtained which are equal in frequency butdifferent in phase by 90 degrees according to velocity direction. Thesesignals are commonly referred to as quadrature audio. When presented tothe quadrature audio demodulator, if, for instance, the first channel isleading the second channel by 90 degrees, i.e., flow "toward the probe",the analog voltage at the output would be a positive value linearlyrelated to the Doppler frequency. If, on the other hand, flow is awayfrom the probe, the phase relationship will be reversed and the analogvoltage at the output would have negative value in relation tofrequency.

In the past, Doppler-shifted audio signals have been processed forvisual inspection by fast Fourier transforms, Kay sonograms and directfrequency-to-voltage conversion by "zero crossing rate meter". All ofthese techniques have their strong and weak points. The zero crossingrate meter is simply a low-cost frequency-to-voltage converter, whereinthe conversion is made by integrating pulses of constant amplitude andwidth which are generated when the Doppler frequency signal crosses azero voltage reference.

Three common faults of the zero crossing rate meter are as follows: (1)false counts can occur when noise is present, which may cause extracrossings, (2) counts can be missed if a low frequency component ispresent, allowing the higher frequencies to ride above or below the zerolevel (riding high syndrome), (3) unpredictable phase shift between thequadrature channels can occur resulting in a loss of flow directioninformation. These conditions are the rule rather than the exceptionwhen processing back- scattered signals from deep vessels. Theintroduction of hysteresis and filters into the circuit may lessen thenoise problems but introduce phase errors that degrade the importantdirection determination.

BRIEF STATEMENT OF THE INVENTION

The present invention is directed to a method and apparatus forimproving pulse Doppler diagnostic systems, and overcoming the aboveproblems of the known arrangements.

In accordance with one embodiment of the invention, in order to improvethe ability of the operator to locate targets, the concepts of echopulse transmission and pulse Doppler transmission are combined, withecho pulse receiving times being interlaced with pulse Doppler signals.With this arrangement, the time interval between echo pulses preferably(although not necessarily remains constant, with the pulse repetitionrate of the Doppler pulse bursts, within a given cycle, being variableif desired. The advantages of Doppler pulse diagnosis are henceretained, while enabling a "look ahead" feature by the use of the echopulses.

In a further embodiment of the invention, the transmitted power of theultrasound pulses for pulse Doppler measurements is controlled toautomatically track the range gate depth setting. This feature increasesthe signal-to-noise ratio for all range gate depths by optimizingtransmitted power for a given depth.

In a still further feature of the invention, the Doppler pulserepetition rate is controlled to vary inversely with the range gatedepth setting. As a consequence, the effective data sampling rate ismaximized.

In a still further feature of the invention, the received Doppler pulsesignals are passed through two tunable filters. (1) A high frequencycutoff filter for decreasing the cutoff frequency automatically as therange gate depth increases. In addition, this high frequency cutofffilter removes the Doppler repetition rate frequency, while preservingall frequencies which carry valid velocity information. (2) A tunablelow frequency cutoff filter is also used to remove low frequency signalsrelating to very slow velocities of no interest such as vessel orcardiac wall motion. The low frequency roll off is normalizedautomatically (in this system) to velocity as probes of differingfrequencies are selected by the operator. The operator may select a lowvelocity roll off such as 0.05 meters/sec for peripheral vascular and0.1 meters/sec for central cardiovascular examination. This arrangementfurther increases the signal-to-noise ratio of the system.

In a still further feature of the invention, separate probes areprovided for separate measurement frequencies,

preferably in the range of 1-7 MHz. The separate probes each have narrowband amplifiers with their impedances critically tuned to the probecrystal to minimize Johnson noise and to provide the maximalsignal-to-noise ratio obtainable at the specific frequency.

In a still further feature of the invention, a full wave quadratureaudio demodulator is provided for detecting the voltage maxima andminima, as an economical means for obtaining a mean velocity signal. Thedemodulator preserves the phase relationship and the magnitude of thevelocity and, unlike conventional zero-crossover detectors, isinsensitive to base line voltage shifts and low frequency noise.

In accordance with the invention it is recognized that zero crossingrate meters require a signal-to-noise ratio greater than 10 forreasonable accuracy.

Yet another feature of this invention is the capability of using theinstrument in the continuous Doppler mode as well as in the pulsedDoppler mode. The mode may be selected by a switch on a split crystalprobe. The same low noise impedance matching network and amplifier areused.

BRIEF FIGURE DESCRIPTION

In order that the invention will be more clearly understood, it will nowbe disclosed in greater detail with reference to the accompanyingdrawings wherein:

FIG. 1 is an illustration of the use of an ultrasound transducerdetermining the velocity of blood in various vessels.

FIG. 2 illustrates the principle of echo pulse transmission systems;

FIG. 3 illustrates vessels at various depths in a tissue;

FIG. 4 illustrates the principle of continuous wave ultrasounddiagnostic systems;

FIG. 5 illustrates the principle of pulse Doppler diagnostic systems;

FIG. 6 illustrates the principle of the combined echo pulse and pulseDoppler diagnostic system in accordance with the invention;

FIG. 7 is a block diagram illustrating a Doppler pulse transmissionsystem in accordance with the invention, wherein the power of the pulsesis controlled as a function of depth;

FIG. 8 illustrates the use of range gates in a pulse Doppler diagnosticsystem;

FIGS. 9a-9d illustrate the relative reception of pulses in echo andpulse Doppler systems, and FIGS. 9e-9g illustrate the variation of pulserepetition frequency, as a function of depth, in accordance with theinvention;

FIG. 10 is a diagrammatic illustration of a transducer;

FIG. 11 is block diagram illustrating the transmission and timingcircuits of an ultrasound diagnostic system in accordance with theinvention;

FIG. 12 illustrates the probe and demodulator circuits of the ultrasounddiagnostic system in accordance with the invention;

FIG. 13 illustrates the filter circuits of the ultrasound diagnosticsystem in accordance with the invention;

FIG. 14 illustrates the demodulation circuits of an ultrasounddiagnostic system in accordance with the invention;

FIG. 15 illustrates a prior art interconnection between the ultrasoundcrystal and the receiver amplifiers;

FIG. 16a illustrates the output of one peak detector;

FIG. 16b illustrates the output of the other peak detector;

FIG. 17 is a simplified diagram of a preferred embodiment of thequadrature amplifier/demodulator in accordance with the invention;

FIG. 17a illustrates an operational amplifier circuit;

FIG. 17b illustrates a modification of the circuit of FIG. 17a;

FIG. 17c illustrates a peak detector derived from the circuit of FIG.17b;

FIG. 18 is a block diagram of the system of the invention interconnectedwith suitable displays, recording devices, etc. for use.

FIG. 19 is a block diagram of an anti-jitter circuit; and

FIG. 20 is an exploded view of a swivel probe.

DISCLOSURE OF PREFERRED EMBODIMENT

The present invention relates primarily to a "pulsed Doppler" systemalthough it may employ "continuous wave Doppler" and "echo" systems.FIG. 1 illustrates an ultrasound transducer 100 which is capable of bothtransmitting and receiving ultrasound pulses. The transducer 100 isplaced against the surface of the skin 110 (or other body of the objectto be examined), and directs ultrasonic signals 120 at blood vessels130, 160 and 180. The blood in the vessel 130, for example, may bemoving in the direction of arrow 140 or in the direction of arrow 150.Using echo technology, a single ultrasonic pulse 200 is transmitted asshown in FIG. 2. In this instance the blood vessel 130 reflects theultrasonic pulse 200 and the transducer receives the reflected pulse 210after a delay in time ΔT has occurred.

Conventionally the received echo pulses reflected from vessels andtissue strata are processed and can be displayed on a monitor scope suchas that depicted in FIG. 3. Typically measurements can be made directlyfrom the display as to vessel diameter, wall thickness, heart valvemovement, etc.

According to continuous wave Doppler technology, the transmittedcontinuous wave signal 300 is shown in FIG. 4. Upon hitting the bloodflowing in blood vessel 130, the continuous wave of cycles 300 arereflected back and are received as reflected cycles 310a or 310b. Cycles310a are reflected pulses of higher frequency, indicating that the bloodis flowing in the direction of arrow 150, and reflected pulses 310b areof lower frequency, indicating that the blood is flowing in thedirection of arrow 140. By determining the difference in frequenciesbetween the transmitted frequency 300 and the received frequency 310,not only can the direction of the blood be ascertained but thedifference in frequency is proportional to the velocity of the blood.

A pulsed Doppler technique, shown in FIG. 5, utilizes a pulsed wave form400 occurring at periodical intervals. After a delayed time period ΔT,the reflected cycles 410a (or 410b) are received by the transmit/receivecrystal 100. Again, the frequency of the reflected pulse 410 determinesboth the direction and the flow velocity of the blood in vessel 130.

Typically pulse 400 consists of a burst of 4 or 8 cycles of the transmitfrequency. In either the continuous wave or pulsed Doppler technique thetransmit signal 300 or 400 will reach all three vessels 130, 160, and180, shown in FIG. 1, in its path and Doppler-shifted signals 410a or410b will be received from all three vessels. The receiver in continuouswave Doppler systems has no way to discriminate between the signalsreflected from the three vessels and will, unfortunately, give a meanflow velocity of the blood flowing in all three vessels. On the otherhand, in the pulsed Doppler system the cycles 410 reflected from vessel130 will be received at the crystal 100 at a time ΔT later than thetransmit burst 400. By applying a time gating technique (commonly knownas range gate) to the receiver, to be discussed later, only the signalsreceived from vessel 130 will be amplified and processed for determiningblood flow velocity and direction. If so desired, the range gate may bemoved to precisely measure the velocity and direction of the bloodflowing in vessels 160 or 180.

While the present invention is primarily directed to the providing of animproved system using the pulsed Doppler and continuous wave techniquesof the type shown in FIGS. 4 and 5, in accordance with one embodiment,to be now discussed, an echo pulse is interlaced with the pulsed Dopplerbursts.

ECHO PULSES INTERLACED WITH PULSED DOPPLER BURSTS

As shown in FIG. 6, one embodiment of the present invention interlacesthe conventional echo pulse of FIG. 2 with the Doppler pulses of FIG. 5.The echo frame of, for example only, 200 microseconds for the echo pulseis constant. Two hundred microseconds is sufficient time for anultrasonic pulse to travel 15 cm into human tissue (the practicalmaximum depth of penetration). This serves a very useful function whichwill be explained by reference back to FIG. 1. In FIG. 1 deeper bloodvessels 160 and 180 are present. In accordance with the techniques ofthe present invention, as shown in FIG. 6, the system of the presentinvention can measure the blood flow in blood vessel 130 based upon thesequences of pulses 400A of pulsed Doppler signals 400.

As will be subsequently explained, the pulse repetition frequency (PRF)of the pulsed Doppler signal 400 can be tuned precisely to allow themeasurement of the blood flowing in vessel 130. Because of this precisesetting of the PRF, the Doppler pulses of the deeper vessels 160 and 180will not be received. By interlacing the echo pulse 200 with the pulsedDoppler signal, and allowing the fixed time period of 200 microseconds,signals may be received from greater depths and the signals from vessels160 and 180 will be present and displayed on the monitor scope shown inFIG. 3. It is important to note that the echo pulse is a single cycle ofthe transmit frequency, thus providing the maximum resolution to theecho signal to be displayed. Hence, the interlaced echo pulse 200provides "look ahead" information which aids in the use of the system ofthe present invention. For example, an operator of the present inventioncan quickly tune the pulsed Doppler signal 400 on any one of severalblood vessels, based upon the "look ahead" information provided by theecho pulse.

In the same manner this arrangement allows the operator to moreprecisely place the range gate in the center of the vessel or chamber inwhich the blood velocity is to be measured. The echo signals and thereflected Doppler signals are separately processed by the system of thepresent invention.

In the preferred embodiment of the present invention, as indicated inFIG. 6, the generation of the echo pulses 200 is approximately a 500 Hzsignal whereas, the generation of the pulsed Doppler signals, PRF of thebursts, is continuously variable from 24,000 Hz to 5,000 Hz. The echotransmission is synchronized with the Doppler transmission and the echopulse is of fixed amplitude in a fixed time frame. As will be explained,the Doppler pulse time frame is variable and the amplitude is alsovariable.

CONTINUOUS MODIFICATION OF THE PRF SIGNAL

This embodiment of the invention is directed to the modification of thePRF of the pulsed Doppler signals, which may be employed with or withoutthe above-disclosed interlacing with echo pulse signals. The range of1-7 MHz for the Doppler frequency is the preferred frequency range forthe Doppler pulses 400 shown in FIG. 5. The higher the transmitfrequency, the greater the shift in frequency because of the Dopplereffect on the reflected signal. This, of course, enables greaterresolution in determining the velocity of the blood. The high frequency(e.g., 7 MHz) is especially suited for examining smaller vessels such asthose found in children. However, the lower the frequency the better theability of the ultrasound to travel through human tissue. Hence, lowerfrequencies (e.g., 1 MHz) are used to measure the flow of blood indeeper tissues.

Another matter of great importance in the pulsed Doppler technique isthe phenomenon of "signal aliasing." Using the pulsed Doppler technique,the Doppler-shifted signal returned from vessel 130, for example, issampled only once in each transmit frame T_(PRF). As predicted by thesample theorem the maximum detectable Doppler-shifted frequency can beno greater than one half the sample rate, which is the same as thetransmit repetition rate (PRF). If the Doppler-shifted frequency exceedsone half the PRF, "aliasing" will occur and the signal represents theblood flow velocity in a useless manner. The first step conventionallyto take when aliasing might occur is to sacrifice the higher resolutionobtained from a higher frequency transducer and move to a lower transmitfrequency, e.g., 1 MHz. In accordance with the present invention thehighest PRF is maintained for all measurements regardless of depth andregardless of probe frequency. This is achieved in this invention byproviding a continuously variable PRF, the PRF being determined by thedepth setting of the sample gate. In other words, a continuouslyvariable PRF that tracks the sample gate, i.e., the transmit burst 400,is initiated almost instantly upon completion of taking a sample at anydepth.

The present invention, therefore, tailors the pulse repetition frequency(PRF) to the depth of the blood vessel being examined. The PRF is thefrequency at which the Doppler pulses are transmitted, which in FIG. 5has a period of T_(PRF). The period of T_(PRF) contains preferably fourcycles at the desired frequency between 1 to 7 MHz occurring in timeT_(DP), and a window of time T_(w) in which the receiver 100 receivesreflected pulses.

The invention thus provides a pulsed Doppler signal 400 which has itsPRF continuously variable so that it can be set at precisely the depthof the blood vessel to be analyzed, and further provides a narrow bandgate, commonly known as the sample volume, to gate the reflected Dopplersignal into the receiver only from that depth. Hence, the presentinvention utilizes a depth control circuit which effects are-transmission of cycles 400 at the end of the sample periods, thuseffecting the maximum obtainable PRF, while examining the blood flowfrom a vessel at that depth.

The control 600 shown in FIG. 11 can thus, for example, be continuouslyadjusted to examine a blood vessel between 0.5 and 17 cm deep in humantissue. The control 600 simultaneously adjusts the range gate (i.e., thetime delay between the pulsed Doppler transmit burst and the receivedsignal gated to the receiver and the PRF, since the succeeding pulsedDoppler burst is transmitted with a fixed delay following the rangegate.

The operation of the depth setting feature of the invention will now bediscussed. In FIG. 7, the transducer 100 receives transmitted pulsesfrom circuit 700 and, in turn, delivers received pulses to receiver 710.A demodulator 720 compares the received pulses with the transmittedpulses to output a difference signal relating to the Doppler shift. Withreference back to FIG. 1, Doppler signals are reflected from the shallowblood vessel 130 as well as from the deeper blood vessels 160 and 180.

FIG. 8 shows the transmitted pulse 400 as well as the reflected pulses800 from the first blood vessel 130 and the reflected pulse 810 from thedeeper blood vessel 160. The present invention, by providing theabove-described variable control is capable of selectively receiving thereflected pulses 800 or 810 by adjustment of a "range gate" window 820to only receive reflected pulses from a desired depth. For example,assume that blood vessel 130 of FIG. 1 is to be analyzed. This is ashallow blood vessel and, therefore, a high frequency Doppler pulse,closer to 7 MHz, is desired. According to the present invention, as willbe subsequently explained, a higher frequency is delivered by transducer100 into the tissue and the control 600 is set for the proper shallowdepth, for example, 3 cm deep. Because it is known that ultrasound isdelayed approximately 13.6 microseconds per centimeter of distance tothe reflector, a "range gate" window 820 is set approximately 80microseconds after the transmission of the Doppler pulses to receiveonly the reflected Doppler pulses 800 from vessel 130.

This window, as shown in FIG. 8, is termed the range gate 820. Thecharacteristics of the range gate need to be discussed. First, theposition of the range gate can be adjusted by setting the control 600 toany position in time T_(w), of FIG. 5, which corresponds to the desireddepth. Hence, should the reflected Doppler signal from blood vessel 160be analyzed, the range gate 820 can be shifted in time (or depth) to thelocation shown in dotted lines as 820A, which then would analyze onlythe received pulses also shown in dotted lines. In other words, therange gate 820 is selectively adjustable in time (or in depth) toreceive only reflected pulses from desired blood vessels.

The interrelationship between the interlaced echo pulse and thetransmitted pulsed Doppler signals, as shown in FIG. 6, will now bediscussed with reference to FIG. 9. The generation of the echo pulse 200results in a received trace in FIG. 9a of three blood vessels, withpulse 900 corresponding to the echo pulse from blood vessel 130, pulse910 corresponding to the reflected pulse from blood vessel 160, andpulse 920 corresponding to the reflected pulse from blood vessel 180.The window 820 can be moved by adjusting control 600 to various depthscorresponding to the depths of each of these blood vessels. Hence, FIG.9b shows the Doppler signal reflected from blood vessel 130 on the echopulse display, with the window set for the depth of vessel 130. When thewindow is moved deeper to analyze the reflected Doppler pulses fromblood vessel 160, the Doppler signals shown in FIG. 9c are reflectedfrom blood vessel 160. And finally, FIG. 9d shows the reflected Dopplersignal when the range gate is set for the deepest blood vessel 180. Itis important to note that the amplitudes of the deeper-reflectedultrasonic pulses are lower. (FIGS. 9b-9d do not necessarily depict anactual display.)

In analyzing FIGS. 9a-9d it can be observed that there is no reason toever receive any additional reflected Doppler signals fromdeeper-located blood vessels since the setting of the range gatedetermines the desired depth. Therefore, as shown in FIGS. 9e, 9f, and9g (which show only the reflected Doppler signals), the Doppler pulse400 is retransmitted at a fixed time T after the range gate setting.Hence, adjusting the control 600 to different depths, tailors theretransmission of the pulsed Doppler signal 400 to occur a fixed timeafter the generation of the range gate. This feature in accordance withthe invention continuously varies the PRF of the system. This is furtherexplained with reference to FIG. 5, where T_(w) is the overall window oftime from transmission to retransmission of pulses 400. T_(w) isvariable since retransmission occurs immediately (i.e., T) after therange gate setting. Thus, for example, for a depth setting of 2 cm, 66bursts of pulses 400 are transmitted in the 1.8 msec time span shown inFIG. 6, whereas for a depth setting of 7 cm only 20 bursts of pulses aretransmitted in the same time. Hence, the pulse repetition frequency isvariable in accordance with the range gate depth setting even whenoperating in the interlaced mode.

In other words, the system in accordance with the invention receives allof the "look ahead" echo pulses interlaced with the Doppler pulses, butignores all reflected Doppler pulses from vessels deeper than the onebeing analyzed, and immediately retransmits the Doppler signal at afixed time T later. The transmission of the pulsed Doppler signal thustracks the range gate. FIG. 9e corresponds to the situation in FIG. 9b,FIG. 9f corresponds to the situation in FIG. 9c, and FIG. 9g correspondsto the situation depicted in FIG. 9d.

In addition, the width W of the range gate can be selectively adjusted.The changing of the width W of the range gate does not affect theretransmission time T.

While the time T is fixed at depths greater than 3 cm, at depths lessthan 3 cm the reflected signals from the surrounding blood vessels ortissue overlap the transmitted signals, thereby destroying rangeresolution. Therefore, at depths less than 3 cm the range gate windowcan be selectively adjusted to shallow depths, however, in accordancewith a further feature of the invention, the retransmission will notoccur until approximately 40 microseconds to eliminate the overlappingof signals.

The above-disclosed system of the invention, by means of a depthcontrol, is capable of tuning in or receiving only the reflected Dopplersignals from blood vessels at a desired depth by selectively adjustingthe range gate. The retransmission of the pulsed Doppler signal occurs afixed time after the setting of the range gate so that the PRF iscontinuously varied as a function of the depth of the vessel. Thisincreases the accuracy and the resolution of the reading while reducingthe probability of aliasing. At depths less than 3 cm, however, theretransmission of the signal occurs at a fixed PRF even though the rangegate can be selectively adjusted to tune in blood vessels shallower than3 cm.

MINIMIZATION OF ELECTRICAL NOISE

According to a further feature of the invention, several separate probesare utilized. Each of these probes is designed to transmit and receiveat a specific frequency, for example:

Probe 0--1 MHz

Probe 1--2 MHz

Probe 2--3.25 MHz

Probe 3--5 MHz

Probe 4--7 MHz

Each of these probes, as shown in FIG. 10, contains a narrow bandamplifier 1000, a swivel head 1010 carrying transducer 100 and anelectrical cable 1020. In accordance with the invention, the first stageof the receiving amplifier 1000 is in the probe. This first stage is anarrow band amplifier with a fixed gain. The narrow band amplifier isdesigned to receive signals at its optimum electrical signal-to-noiseratio. The power of the transmitted signal (wave form 400 of FIG. 6) isthen adjusted to accommodate the depth of the vessel being analyzed. Itis recognized that attenuation of an ultrasound signal increases as thesquare of the distance involved. Hence, in adjusting the depth control600, as shown in FIG. 7, the power 730 delivered to the transmitter 700is increased according to the depth of the blood vessel being analyzed:the greater the depth, the greater the power.

Hence the transmit power delivered to the crystal for Doppler pulses 400is continuously variable and automatically adjusts to the depth to bepenetrated as control 600 is adjusted. Attenuation in human tissue ofthe transmitted Doppler frequency 400 increases as the transmitfrequency is increased. Therefore, as the transmit frequency 400 isincreased, the transmit power is also increased automatically tocompensate for attenuation. This is contrary to prior devices where thepower is fixed at a constant value while the range gate is moved todifferent depths, and transmit frequencies are changed. Some knownapproaches do, in fact, have a separate operator control for manuallyadjusting the power level. Such controls do not automatically track therange gate setting as specifically done in accordance with the presentinvention.

This is an extremely important feature of the present invention. Bydesigning several separate probes each having a narrow band amplifier atits optimum signal-to-noise ratio configuration contained therein andthen automatically modifying the transmitter power to increase the powerfor greater depths of penetration, extremely high signal-to-noise ratiosare obtained.

Doppler signal processing becomes complicated by the fact that signallevels reflected from solid structures such as walls and valves areorders of magnitude greater than reflections from red cells. Thestronger signals have a tendency to saturate the receive electronics andmask the desired Doppler signals. This is especially true inconventional systems where the transmit power is held constant, near themaximum of 100 mW/cm² crystal area. Even the best damped crystal willhave a longer ringing time and generate spurious reflections in the nearfield when full power is applied. Lowering the gain of the probeamplifier for near field visualization, conventionally referred to asrange gain, does help but is not as effective as fixing the gain of theprobe amplifier at the optimum signal-to-noise ratio and thencontinuously tailoring the transmit power to compensate for thepredicted attenuation for a given depth. In accordance with theinvention, at low tissue depths, low power is automatically provided.The system is designed to meet the standard of no more than 100 mW/cm²at its maximum power position. This is a standard set by the industry.Hence, the average power delivered to the human tissue is maintainedbelow 100 mW/cm² under all conditions.

ELECTROSTATIC SHIELDING OF THE TRANSDUCER

In medical applications where life support instruments such as EKG, EMB,intravenous machines, etc. are connected to the patient, spuriouselectrical signals are quite often generated by the life supportequipment and electrically coupled to the transducer when the transducercomes in contact with the patient. The transducer 100 of FIG. 10 in thepresent invention is electrostatically shielded to prevent the pickup ofsuch electrical noise.

As shown in FIG. 12, the transducer 100 is comprised of crystal 1110conventionally interconnected to an output. In front of the crystal isconventionally placed epoxy layer 1130. A metallic layer 1150 isprovided over the top of the epoxy 1130 and surrounding the edge of thecrystal. A further epoxy layer 1140 is provided on the metallic layer.Of course, a variety of approaches can be utilized to provideelectrostatic shielding to this probe tip. A wire screen could take theplace of the layer 1150 or the like. It is important to note thatelectrical noise from the patient is intercepted by the electrostaticshield and is taken to the output of the amplifier rather than to theinput so that the input signals to the amplifier are not subject to thisnoise. The need for the shielding is especially apparent when thesignal-to-noise ratio of the probe electronics is increased to the levelof this invention. In known devices having a significantly lowersignal-to-noise ratio, sources of noise at this level are less apparent.

MINIMIZATION OF JOHNSON ELECTRICAL NOISE

As previously indicated, each narrow band amplifier 1000 isinterconnected over cable 1020 to a wide band receiver 1200. One sourceof noise in ultrasonic systems, and in other systems where noise is aproblem, is electrical noise caused by the electrical components of thesystem. One of the chief "noise" generators is the resistor in theconventional wide band receiver used in ultrasonic detectors. This isshown in FIG. 15 wherein the transducer 100 is connected through avoltage dropping resistor 1300 through a set of clamp diodes 1310 andinto the amplifier 1320. The resistor 1300 is a primary electrical noisesource in such conventional approaches.

The function of resistor 1300 in conventional designs is to prevent theamplifier protection diodes 1310 from shorting the transmit signal toground during the transmit period. If the resistor 1300 is too small, alarge portion of the transmit energy will be lost via resistor 1300 andamplifier protection diodes 1310 to ground. On the other hand, if theresistor 1300 is made too large, a portion of the receive signal will belost according to the voltage divider effect of the resistor 1300 andthe input impedance of amplifier 1320. A very significant source ofnoise is the Johnson noise of the resistor 1300 which increases as theresistance of resistor 1300 is increased. The present inventioneliminates the use of this resistor. In the circuit shown in FIG. 12 thetransducer 100 is connected through two diodes 1400 to the transmitcircuit T. This is conventional. The transducer 100 is also connected inparallel across a capacitor 1410 and across the primary of a saturablecore transformer 1420 to the receive circuit. The secondary oftransformer 1420 is, in turn, connected in parallel to a variablecapacitor 1430 which is in parallel across the pair of clamping diodes1310 and to the input of amplifier 1320. As is apparent, the resistor1300 of conventional circuits is eliminated.

During transmission of the Doppler pulse, the reactive components ofcapacitor 1410 and of the primary of saturable core transformer 1420 aretuned so that the voltage and current components are in phase (i.e., noreactive loss) and all energy from the transmitter is directly appliedto the crystal 1110 and converted into ultrasonic energy. Of utmostimportance is the construction of transformer 1420. The core material,placement of the primary and secondary windings, as well as the type ofwire used is critical. Specifically, the transformer is designed toefficiently transfer the low level receive energy from the crystal toamplifier 1320 (i.e. with no greater than critical coupling). On theother hand, the coupling is such that the high level signal during thetransmit period will detune the secondary and effect a minimalabsorption of the transmit energy.

Hence, during the transmit phase, the receiver circuit is completelydetuned from the transmit frequency. In the transmit phase, the onlyimpedance in the circuit is the 50 ohms of the crystal 1110. During thereceive time, any signal received by the crystal 1110 is converted intoelectrical energy and is delivered into the primary of transformer 1420and is stepped up by a factor of 10. Again, because of the matching ofthe reactive components of capacitor 1430 and the secondary oftransformer 1420, the reactive loss is substantially zero and thestepped up signal is delivered directly into the amplifier 1320. It isrecognized that noise generated by components at the input Io amplifier1320 is decreased by the square of the turns ratio of the transformer1420.

Hence, the circuit of the present invention, as shown in FIG. 12,provides a signal-to-noise ratio five to ten times better thanconventional approaches because it uses a narrow band circuit designedfor a specific frequency (i.e., the frequency of one of the severalprobes) to have extremely low component noise. This is a significantincrease in the signal-to-noise ratio of the design of ultrasonicsystems. Hence, by utilizing a narrow band amplifier concept, aspreviously discussed, the Johnson noise directly attributable to theresistor 1300 in conventional circuits can be minimized by utilizing thetransformer and capacitor circuit as shown in FIG. 12. The onlysignificant noise left in the circuit of FIG. 12 is the crystal noise atroom temperature. In comparison to wide band amplifiers of conventionalband width, i.e. 5 MHz, the narrow band amplifier 1000 of the presentinvention has an approximate 1 MHz bandwidth. Furthermore, the circuitof FIG. 12 is readily adaptable at the factory to the frequencies ofeach of the several probes.

As shown in FIG. 12, the second stage of amplification which is remotefrom the hand-held probe is a wide band receiver capable of receivingthe several separate probes of the present invention. The wide bandreceiver 1200 is designed to receive 1-10 MHz and will accommodate anyone of the several probes. An impedance matching circuit as shown inFIG. 15 is utilized to connect each of the probes to the wide bandreceiver 1200.

CONTINUOUSLY TRACKING PRF FILTERS

As mentioned above, the pulse repetition frequency (PRF) is varied byretransmitting the Doppler pulse bursts at a fixed time, T, after thecessation of the range gate. Since there is only one sample of thesignal taken in each Doppler transmit frame, the range-gated samplefrequency is the same as the PRF. According to the sample theorem, themaximum detectable Doppler shifted frequency is slightly less than onehalf the sample frequency. Therefore, the high frequency roll-offcharacteristics of the low pass PRF filter 1608 has a 3 db point at onehalf the PRF with a steep roll-off of 72 db/octave, i.e., 72 dbattenuation at the PRF. Of course, this filter, according to theinvention, tracks the PRF continuously. As discussed with reference toFIG. 12, the received signals are applied to dual demodulators 1600 suchas product detectors and 1602. Here the received signal is compared withthe transmitted oscillator frequency in 1600 and the transmittedfrequency shifted 90 degrees in phase in demodulator 1602.

This demodulator feature is known and produces two signals, one leadingand one lagging (this is commonly referred to as quadrature audiosignals). For example, if a signal from demodulator 1600 leads, then theblood is flowing in one direction whereas if it lags the signal fromdemodulator 1602, then the blood is flowing in the other direction. Thedemodulated signal is applied to a range gate circuit 1604, 1606 which,as previously discussed, allows the system to analyze the reflectedsignals only in a predetermined range of time. The reflected Dopplershift frequencies are then applied to dual voltage tunable PRF filters1608 and 1610 (FIG. 13). These dual low pass filters have tunable highfrequency cut-off characteristics which remove the high frequency PRFsignals. As discussed, the PRF frequency is higher at shallow depths andlower at greater depths. Therefore, the tunable filters decrease theircut-off frequencies at greater depths. Previous systems utilized anumber of fixed PRFs and matching filters. Using this method, theoptimal PRF is seldom achieved for a given depth. In addition, aselectable low frequency cut-off filter is provided to remove lowfrequencies, including possible beat frequencies seen in FIG. 13, thecutoff of the high pass filters 1612 frequency may be selected by theoperator, with the switch 2051, in terms of blood velocity rather thancycles, the setting being normalized to all probe frequencies by filterselect 2050. These filters remove the Doppler pulse repetition ratefrequency and slow-moving wall frequencies from the audio signals whilepreserving all frequencies which carry valid velocity information.Hence, referring to FIG. 13, as the tracking circuit which is controlledby the control 600 of FIG. 11 is set for greater and greater depth, notonly is the power to the transmitter increased but also the PRF cut-offfrequency is decreased.

PEAK SWITCHING FULL WAVE QUADRATURE AUDIO DEMODULATOR

The signals are then delivered into an audio demodulator 1705. The audiodemodulator 1705 (FIG. 14) processes the signals from the tunable PRFfilters 1608 and 1610 into a clean signal for display purposes. Thequadrature audio demodulator of the present invention has the followingcharacteristics:

1. Works well with signal-to-noise ratios as low as 1.5 to 1.

2. Has a wide dynamic range (1000 to 1)--signal levels from 10 mVpeak-to-peak to 10 V peak to peak.

3. Completely ignores the riding high syndrome.

4. Maintains phase relationships of the quadrature signals, for accurateflow direction determination.

5. Provides a threshold adjustment to eliminate background noise.

6. Operates over a frequency bandwidth from 10 Hz to 20 kHz with nosignificant phase shift over this entire frequency band.

7. Low cost; uses only six low-cost integrated circuits.

8. Uses full wave demodulation for fast responses and accuracy.

9. Provides a fast rise time (15 ms to 90% rise time).

10. The output voltage follows the mean of the velocity distribution.

This feature of the invention is best described by reference to FIG. 14.Signals from the PRF filters 1608 and 1610 are delivered into dual peakdetectors 1700 and 1710. These peak detectors receive signals as shownin FIG. 16 from the PRF filter 1608 and 1610. The two signals areidentical except they are separated by 90 degrees in phase. The Dopplersignal which is represented by the sinusoidal curve may be riding onanother curve such as a DC level or other level. The purpose of the peakdetectors 1700 and 1710 is to eliminate the effects of these otherlevels including low frequency noise and base line voltage shifts.

Hence the need exists for the detection of the maxima and the minima ofthe Doppler-shifted audio signals shown in FIG. 16, rather than thedetection by a conventional zero crossing detector. The peak detectors1700 and 1710, through a unique gain switching technique, provide aconstant level output signal which reverses precisely at peakturn-arounds, shown as 1608A, B, and C. However, note the perturbationsdenoted by 1608D. The output signal has gain but it is insufficient toreach the levels 1608E or 1608F. Herein lies the key to the operation ofthe demodulator circuitry. The circuit components can be adjusted toreject small excursions such as 1608D, thus providing a means ofrejecting instrument background noise, while meeting the specificationslisted above.

Since the peak detectors determine most of the desirable characteristicsof the quadrature audio demodulator, they will now be discussed ingreater detail. The peak detection circuit is obtained from theconventional operational amplifier circuit of FIG. 17B by the additionof a non-linear feedback element, as shown in FIG. 17C and as will bedescribed hereinafter.

Operation of the circuit of FIG. 17B, as it is employed for thispurpose, is more readily understood with reference to the simplercircuit of FIG. 17A. If the amplifier 1768 of FIG. 17A is chosen to havecharacteristics similar to the LF357 integrated circuit operationalamplifier, the circuit of FIG. 17A will have a gain of C1/C2, where C1and C2 are the capacitances of capacitors 1770 and 1772 respectively,over the frequency band of interest, i.e., from 20 Hz to more than20,000 Hz, provided the capacitances are small. For example if C1=3000pf and C2=10 pf, the circuit of FIG. 17A will have a gain of 300 andthere will be no significant phase shift since the circuit resistancevalues are large, i.e., the input impedance of the amplifier 1768 is10¹² Ω.

If we add to the circuit of FIG. 17A resistors 1774 and 1776 havingresistances R1 and R2 respectively, shown in FIG. 17B, where R1 issmall, for example, R1=50Ω, and R2 is very large, for example, R2=2×10⁹Ω, the performance is improved by the damping properties of resistor1774 and the ability of resistor 1776 to minimize the zero drift when nosignal is present. The values of R1 and R2 are such that the changes inthe gain and phase shift characteristics from those of FIG. 17A are notsignificant.

In the peak detection circuit shown in FIG. 17C, transistors 1778 and1780 have been added. Transistors 1778 and 1780 are connected asback-to-back zeners that are selected for the following characteristics:(1) low capacitance, (2) extremely sharp break point, and (3) fastresponse. Transistors such as the 2N2222 function well in this mode.When the reverse-biased zener of the transistor pair 1778, 1780 is notconducting, the circuit acts the same as the circuit of FIG. 17B, havinga gain on the order of 300. However, when the zeners are conducting, theimpedance of the feedback element approaches zero; and the circuit actsas a unity gain voltage follower. Note that when the zeners areconducting, the operational amplifier operates in such a way that theinput node P is held at a potential which differs from the outputvoltage E_(o) by a fixed amount approximately equal to the zenervoltage. As the magnitude of the output E_(o) increases, conductionthrough the zeners raises the voltage at P so that this differenceremains constant. Hence, any time the magnitude of E_(o) begins todecrease, the voltage difference between the output and node P dropsbelow the zener voltage, the zeners stop conducting and the gain of thecircuit goes to its high value (e.g., 300).

If the circuit component values are chosen for a gain of 300 and theinput signal is such that the zeners (1778 and 1780) are in theconducting state, instantaneously upon the reversal of direction of theinput signal, the amplifier gain will change to 300, and the outputvoltage will reverse polarity and track the input signal with a gain of300. This condition will continue until the zener level is reached andonce again the amplifier gain will revert back to unity. The amplifierwill remain in this unity gain state until the input signal once againreaches a maximum or minimum and changes direction. On the other hand,if the changes of the input signal are not large enough to reach thezener levels, the output signal will simply track the input signal witha gain of 300.

It is also noted that capacitor 1772 is now drawn in dashed lines sincethe distributed capacitance of the feedback elements may very easily addup to 10 pf and the capacitance C1 can be adjusted to give the desiredcircuit gain.

The pulses are then delivered to the window level detectors 1720 and1730, which eliminate the noise perturbations such as 1608D by extendingpulses only having levels extending beyond 1608E and 1608F. These pulsesare then applied to phase-sensitive, full-wave pulse generators 1740 and1750 comprised of pairs of one-shots, as shown in FIG. 17. Either of thegenerators 1750 or 1740, but not both, will generate pulses of equalamplitude and width depending on the phase of the signals at thatinstant. Thus, the pulses of the leading channel enable the pulsegenerator of the lagging channel. This condition reverses as flowdirection reverses. These pulses are then integrated by the differentialintegrator 1760 to provide blood flow velocity and directioninformation.

For a given velocity of blood flow the Doppler frequency will increaseas transmit frequency is increased. This has been a confusing issue inpast instruments since velocity is given in cycles rather thanmeters/sec. The signal output of this instrument is normalized tometers/sec regardless of transmit frequency and an internal calibratoris provided for operator convenience.

The present invention can now present the above signals for accurate butsimple analysis of cardiac output, velocity and volume blood flow to thebrain, heart valve timing measurements, etc.

THE OPERATION OF THE SYSTEM

As illustrated in FIG. 12, the probe includes a frequency coder 2000 andmode selection continuous wave vs. pulsed Doppler, which may comprise aterminal block having determined shorts. This coder is connected to adecoder 2010 in the demodulation circuit, for controlling automaticallya frequency selector 2020 (for example, an electronic gate) to selectthe corresponding oscillator frequency of oscillator 2030. Thisselection is also effective automatically for the otherfrequency-dependent parameters such as the gain select 2040 of FIG. 14and the normalized filter selection 2050 of FIG. 13.

The oscillator output is applied to the comparator 2060 of FIG. 11,serving to convert the sine wave oscillator output to inverted andnoninverted output. The non-inverted output is applied to adivide-by-eight divider 2070, for synchronization of the start time of arange depth one-shot 2080, the width of the output of the one-shot 2080being determined by the control 600 which may be a potentiometer. Theoutput of the range depth one-shot is applied to the enable input of arange gate width one-shot 2090 for controlling the gate width by meansof a potentiometer 2100. The clock input of the range gate widthone-shot is derived from an anti-jitter circuit 2110, to which adivide-by-four output of divider 2070 is applied. The anti-jittercircuit, which will be described in later paragraphs, insures that thestart of the range gate does not shift relative to the transmit pulse,since shifts even in the nanosecond range can produce undesirableoutputs, i.e., noise that may be larger than the Doppler signal. Thenon-inverted range gate width output is applied to a range sampleone-shot 2120, and thence to a range sample and hold circuit 2130, forproviding an output to a liquid crystal display 2140 for continuouslydisplaying the range gate timing, and hence the depth of the samplevolume.

Retransmit one-shot 2150 determines the time for retransmission of thepulse Doppler burst following termination of the range gate, in order toinsure maximum sampling rates, and one-shot 2160 determines the minimumdelay between successive Doppler pulses. The retransmit one-shot iscontrolled by way of the anti-jitter pulse shaper 2170 and flip-flop2180, to insure that no jitter occurs in the timing of the pulse.

The transmit gate control is started by gate start one-shot 2190, andstopped by the gate stop one-shot 2200, these circuits controlling thegate width circuit 2210 which is comprised of a plurality of flip-flops,e.g., four flip-flops. This circuit controls the number of cycles ineach pulse burst, and may be controlled by an external switch 2220. Theoutput of the transmit gate width flip-flops and the oscillatorfrequency signals are applied to the transmitter amplifier 2230 by wayof NAND gates 2240, 2250, thus controlling the number of cycles oftransmission of the pulse Doppler bursts on lines 2260 to the probe.

The range gate is outputted from the circuit of FIG. 11 on line 2270, toprovide control of tunable filters and gating signals in the receiver atprecise intervals.

When echo pulses are also transmitted, in accordance with the invention,the echo frame is determined by one-shot 2280, and the echo frequency isdetermined by one-shot 2290. This circuit further includes a pre-echominimum one-shot 2300, a one-cycle delay one-shot 2310 and a half-cycledelay one-shot 2320, various one-shots of this circuit being connectedto the NAND gates 2240, 2250 in order to insure the blocking of theDoppler pulses during the echo period. The output of charge echocapacitor one-shot 2330 is applied to the transmitter output transformer2360 by way of transformer 2340 and power MOSFET power amplifier 2350 tocharge capacitor 2335.

In the pulse Doppler mode the transmit power is controlled automaticallywith reference to an operator-selected maximum power level by a control2400. This control allows the operator to select a power range suited toindividual patient variability, for example, an infant versus an olderobese patient. The transmit power is then controlled automaticallyaccording to the range gate time and pulse duration as presentedsubsequently.

Transmit energy levels during Doppler transmission are determined bymonitoring the mean current supplied by the transmit power stage 2230,i.e., a voltage is developed at 2235 proportional to the mean currentsupplied by the transmit power amplifier 2230. This level is compared toa preset reference level as set by control 2410 at the power erroramplifier 2420 which effects a correct voltage level to the power outputstage. In this manner the average current level of the transmit poweramplifier is held constant and the power delivered to the transducer iscontinuously and automatically adjusted as the transmit duty cycle ischanged, for example, by changing the PRF, the number of cyclestransmitted or the frequency of transmission. The desired powerrequirement vs. depth and transmit frequency is thus achievedautomatically.

It is important to note that the transmit voltage requirements may bequite different for the echo frame vs. Doppler frames, i.e., the Dopplermay be operating at a high PRF in the near field and echo frame may bereceiving signals from 17 cm. These requirements are met in thefollowing manner: after the last Doppler frame and prior to the echoframe, capacitor 2335 is charged to 100 volts by echo power circuitry.Thus, the energy for the single-cycle, pulse for the echo frame issupplied by capacitor 2335. Diodes 2450 ensure that there is nointeraction between the pulse Doppler power requirements and the echoamplitude.

The continuous wave line illustrated in this figure enables transmissionof continuous radiofrequency signals to the crystal by enablingoperation of switch 2265, which applies the oscillator output directlyto the probe, in response to the insertion of a continuous wave probe(not shown).

Referring now to FIG. 19, therein is shown one embodiment of ananti-jitter circuit in combination with the range gate synchronizationcircuitry. In this circuit, inverted and non-inverted outputs areprovided from a divide-by-four circuit 3000 whose input is coupled to anoutput of the comparator 2060, the output of the divide-by-four circuitbeing selected via OR gates 3010, 3020, for application to AND gate3030. The output of the AND gate 3030 clocks the range gate one-shot3060 via AND gate 3050.

The output of the one-shot 3060 at terminal 10 is the synchronized rangegate output. One-shot 3070 is clocked via the enable input of theone-shot 3060, and its output at terminal 6 is ANDed with thesynchronized range gate output via AND gate 3080, to control flip-flop3090. The inverted and noninverted outputs of flip-flop 3090 are appliedas the second input of the OR gates 3010, 3020.

The time T_(w) must, in accordance with the invention, be held exactlyconstant, since it has been found that noise within the frequency rangeof the Doppler signal will be generated if the start of the range gateintercepts a slope of the echo signal (as would be seen if the rangegate coincided with a signal from a reflecting boundary) at differenttimes, even with different timings on the order of nanoseconds.

In this system we use the divided transmit frequency as a clock. Thestart of the range gate is synchronized in time with the start of thetransmit pulse and therefore cannot deviate from this timing. In orderto ensure that the timing is positively selected, i.e. does not flipback and forth between clock pulses, the anti-jitter circuitry,comprised of one-shot 3070, AND gate 3080 and flip-flop 3090, selectsthe phase of the clock pulse that will not allow coincidence between theclock pulse and the enable pulse.

PROBE SWIVEL MECHANISM

In a probe having an electrical transducer at its tip, such as anultrasound transducer probe used in medical diagnosis, it is sometimesdesirable to change the orientation of the transducer relative to theprobe handle. The mechanism by which the orientation of the transduceris changed must not twist or stretch the wiring to the transducer.Further, the mechanism should normally be compact, so as not to addexcessive bulk to the probe and the wiring from the transducer to theprobe handle should be protected from mechanical damage.

The swivel mechanism disclosed herein meets these criteria.

The swivel mechanism consists of three major parts, as shown in FIG. 20:the nose portion 4001 (which normally houses the transducer), the probehandle 4002, and the adjusting sleeve 4003. Cylindrical projections 4004and 4005 extend from the nose portion 4001 and from the handle 4002.These insert into mating bores 4006 and 4007 in the adjusting sleeve4003 and are held into these bores by retaining means (not shown) whichpermit the projections to rotate relative to the adjusting sleeve. Theends of the cylindrical projections 4004 and 4005 comprise bevel gears4008 and 4009. These gears are maintained in proper mesh by theadjusting sleeve 4003 and its retaining means.

The angle between the probe 4002 and the nose portion 4001 is adjustedby turning the sleeve 4003 relative to the handle 4002.

The angular orientations of the projections 4004 and 4005 and bores 4006and 4007 determine the range of adjustment of the mechanism. If α is theangle between the axis of the nose portion 4001 and the axis of itsprojection 4004; β is the angle between the axis of the handle 4002 andthe axis of its projection 4005; and ≢ is the angle between the axes ofbores 4006 and 4007, then the maximum range of adjustment is from([α-(180°-γ/2)]+[β-(180°-γ/2)]) to ([α+(180°-γ/2)]+[β+(180°-γ/2)]). Forthe simple, symmetrical case where α=β and α+β+γ=180°, this range isfrom 0 to 4γ. Hence, to obtain an adjustment from 0° to 90°, α and β are22.5°, and γ is 135°.

In order for such a swivel to provide co-axial alignment of the handle4002 and the nose portion 4001 at one extreme of the range ofadjustment, the bevel gears 4008 and 4009 must differ in alignment by1/2 gear pitch relative to the plane defined by the axis of the part andthe axis of its cylindrical projection.

As a matter of preferred design, each of the bores 4006 and 4007 andeach of the projections 4004 and 4005 commences from a plane surfaceperpendicular to its axis. This permits full surface contact between theends of the adjusting sleeve 4003 and their mating surfaces on the probehandle 4002 and nose portion 4001.

Wiring between the transducer and the probe handle is routed throughbores central to the projections 4004 and 4005, for example, bore 4010,and generally through the intersection of bores 4006 and 4007. Sincethis route corresponds approximately to a line of constant length, thewiring experiences essentially no stretching or compression as the noseportion orientation is adjusted.

Since mesh between the gears 4008 and 4009 prevents relative rotationbetween the projections 4004 and 4005, the wiring experiences no twistas the orientation of the nose portion is adjusted.

The wiring through the mechanism is protected from mechanical damage bythe sleeve 4003.

The present invention is thus characterized by the following features:

1. Interlaced "Doppler" and "Echo" Transmitted Pulses Provision ofsingle-cycle ultrasound pulses to provide echo visualization beyond theDoppler range gate setting which are interlaced with a train of Dopplerpulses used for velocity measurements as shown in FIG. 6. The timeinterval between echo pulses remains constant and independent of Dopplerpulse repetition rate (PRF) as does the power of each echo pulse.

2. Transmit Receive Capability--enables the following modes:

A. Using the pulsed Doppler probe:

1. Pulsed Doppler only.

2. Pulsed Doppler interlaced with echo.

B. Using the continuous wave probe:

1. Continuous wave only.

2. Pulsed Doppler only.

3. Pulsed Doppler interlaced with echo.

3. Range Tracking Transmit Power for Doppler Pulses--The transmittedpower of the ultrasound pulses for Doppler measurements automaticallytracks the range gate depth setting so that the greater the depth, thegreater the power. The power at a particular depth setting is chosen sothat the aggregate signal-to-noise ratio for the tissue-receivercombination is nearly maximized for all range gate depths.

4. Range Tracking Pulse Repetition Rate for Doppler Pulses--A reciprocalrelationship is automatically maintained between the Doppler pulserepetition rate and the range gate depth setting. In other words, as therange gate depth is set for greater depths, the Doppler pulse repetitionrate is lowered and for shallower depths, the pulse repetition isincreased. The Doppler pulses are transmitted a set time after the rangegate setting. For any range depth, therefore, this arrangement maximizesthe effected data sampling rate and determines the maximum flow velocitywhich can be measured.

5. Synchronized Range Gate--eliminates noise generated by unsynchronizedrange gate sample times characteristic of other pulse Doppler systems.

6. PRF Tracking Filters--The provision of the dual low-pass filters 1608and 1610, to provide a tunable high frequency cut-off which decreasesthe cut-off frequency as the range gate depth increases. These filtersremove the Doppler repetition rate frequency from the quadrature audiosignals while preserving all frequencies which carry valid velocityinformation for all pulse repetition rates.

7. Dual tunable high pass filters 1612 normalized to low velocity rolloff, i.e. 0.05 or 0.1 meters per second, eliminate velocities of nointerest such as vessel wall motion, artifacts due to breathing, etc.

8. A Plurality of Narrow Band Probe Amplifiers for Received Signals--Theprovision of a plurality of tuned narrow band amplifiers each of whichis actually located in its individual probe and which provides allsignal gain needed for input to a wide band amplifier. The narrow bandamplifier has its input impedance critically tuned to the crystal tominimize Johnson noise and to provide maximal obtainable signal-to-noiseratio at a specific frequency. The output impedance of this amplifier ismatched to the combination of a probe cable impedance and wide bandamplifier input impedance. This amplifier design substantially improvesthe signal-to-noise ratio of the return signal.

9. The velocity output signal is normalized to meters per second.

10. Full Wave Quadature Audio Demodulator--The audio demodulator of theinvention detects the timing of the relative voltage maxima and minimaas an economical means of obtaining a mean velocity signal. Thedemodulator preserves the phase relationship (direction information) andthe magnitude of the velocity. Unlike conventional zero-crossoverdetectors, the circuit of the invention is insensitive to baselinevoltage shifts and low frequency noise. Therefore, it can provide anaccurate flow signal even in difficult clinical situations where theDoppler signal-to-noise ratio may be as much or tenfold below the usefulratio for zero-crosses.

11. Wide Band Amplifier--The use of a wide band amplifier, as shown inFIG. 12, permitting one system to be used with several differentcritically tuned probes at different frequencies typically in the rangeof 1-7 MHz.

12. Electrostatic Shielded Transducer--As shown in FIG. 12, thetransducer of the present invention is electrostatically shielded andgrounded to a separate electrical ground.

13. Swivel Probe--As shown in FIG. 10, a swivel probe is provided. Thecenter of the swivel is hollow to permit the passage of electricalwires. The probe may be swiveled continuously throughout its range ofadjustment without disrupting the electrical connection.

14. Signal Recorder--The invention also incorporates a recorder whichcan record Doppler flow information along with simultaneously measuredphysiological variables.

The quadrature audio demodulator is illustrated in greater detail inFIG. 17. In this system it is noted that the plus-minus peak detectorsare shown for the noninverting mode, but they may be used in theinverting mode. The latter mode is preferable. The system of theinvention, incorporating various displays, and outputs and inputs, isillustrated in FIG. 18.

It is of course apparent that some of the above features haveapplication to areas of discipline other than that of the Dopplerultrasound technology, and it is hence intended that this inventionencompasses such additional application.

What is claimed is:
 1. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and ultrasound transducer means connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for apply signals to said receiving means in response to ultrasound pulses received in response to said emitted ultrasound pulses, the improvement wherein said transmitting means comprises means for generating a train of Doppler pulse signals each comprised of a burst of a plurality of cycles followed by a receiving cycle, means for generating range gate signal for applying gate signals to said receiving means to enable reception of signals, by said receiving means corresponding to said Doppler pulse signals only during predetermined periods following each Doppler pulse signal, means for applying said Doppler signals to said transducer means as said drive signals, and means for adjusting the time between each Doppler pulse signal and the respective range gate signal while maintaining the time between each Doppler pulse signal and the immediately preceding range gate signal substantially constant and while simultaneously varying the power of emitted ultrasound pulses in the same sense.
 2. The ultrasonic diagnostic apparatus of claim 1, wherein said means for generating a range gate signal comprises means for establishing first and second clock signals of opposite phase, and means responsive to substantial coincidence between the leading edge of said range gate signal and one of said first and second clock signals for initiating said range gate signal with the other of said click signals, said one clock signal being that one of said clock signals that initiated the last previous range gate signal.
 3. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and ultrasound transducer means connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses received in response to said emitted pulses, the improvement wherein said transmitting means comprises means for generating a train of Doppler pulse signals each comprised of a burst of a plurality of cycles followed by a reading cycle, means for generating a range gate signal for applying gate signals to said receiving means to enable reception of signals only during predetermined periods following the emission of each Doppler pulse signal, means for applying said Doppler pulse signals to aid transducer means, sand means for adjusting the time between each Doppler pulse signal and the respective range gate signal and maintaining the time between each Doppler pulse signal and the immediately preceding range gate signal substantially constant while simultaneously varying the pulse repetition rate of said Doppler pulse signals.
 4. The ultrasound diagnostic apparatus of claim 3 wherein said means for adjusting comprises means for inhibiting the generation of each Doppler pulse signal until a predetermined minimum delay time following the range gate signal corresponding to the previous Doppler pulse signal.
 5. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and ultrasound transducer means connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses in response to the emitted ultrasound pulses, the improvement wherein said transmitting means comprises means for generating a train of Doppler pulse signals each comprised of a burst of a plurality of cycles, means for generating a range gate signal for applying gate signals to said receiving means to enable reception of signals corresponding to said Doppler pulse signals only during predetermined periods following each Doppler pulse signal, means for applying said Doppler pulse signals to said transducer means as said drive signals, said receiving means comprising low pass filter means, said apparatus further comprising means for adjusting the time between each Doppler pulse signal and the respective range gate signal while simultaneously decreasing the cutoff frequency of said low pass filter means for increases in said time and increasing said cutoff frequency for decreases in said time.
 6. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and ultrasound transducer means connected to said transmitting means for emitting ultrasound in response to said drive signals and for applying signals to said receiving means in response to ultrasound echoes responsive to said emitted ultrasound, the improvement wherein said transducer means comprises a transducer, means connecting said transmitting means to said transducer, a narrow band amplifier and a transformer having a primary winding connected to said transducer and a secondary winding connected to said narrow band amplifier, said transformer being tuned to the frequency of emission of said ultrasound.
 7. The apparatus of claim 6 wherein said transformer comprises a core that saturates when drive signals are applied to said transducer.
 8. The apparatus of claim 6 wherein the coupling between said primary and secondary windings is no greater than critical coupling at the frequency of said ultrasound.
 9. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and ultrasound transducer means connected to said transmitting means for emitting ultrasound in response to said drive signals and for applying echo signals responsive to said emitted ultrasound to said receiving means, and wherein said receiving means comprises means for synchronously demodulating received signals to provide first and second signals demodulated at 90 degrees with respect to one another, the improvement wherein said receiving means further comprises means for peak detecting each of said first and second signals to produce peak detected signals, means for level detecting said peak detected signals to substantially eliminate noise perturbations, phase sensitive full wave pulse generating means connected to said level detecting means, and means for integrating the outputs of said pulse generating means for producing said output signals.
 10. In the method of diagnostic analysis employing Doppler pulse generation comprising generating Doppler pulse drive signals in the form of bursts of a plurality of cycles, applying said drive signals to an ultrasound transducer for transmitting bursts of ultrasound, receiving echo ultrasound pulses responsive to said transmitted bursts via said transducer and applying them to a receiving means, generating a range gate signal and displaying the output of said receiving means during the occurrence of said range gate signal; the improvement comprising adjusting the timing between each said burst and the succeeding range gate signal while maintaining the time between each burst and the immediately preceding range gate signal constant and simultaneously adjusting the power of transmitted ultrasound emitted by said transducer in the same sense.
 11. In the method of diagnostic analysis employing Doppler pulse generation comprising generating Doppler pulse drive signals in the form of bursts of a plurality of cycles, applying said drive signals to an ultrasound transducer for transmitting bursts of ultrasound, receiving echo ultrasound pulses responsive to said transmitted ultrasound bursts via said transducer and applying them to a receiving means, generating a range gate signal, and displaying the output of said receiving means during the occurrence of said range gate signal; the improvement comprising adjusting the time between each said burst and the succeeding range gate signal and simultaneously adjusting the pulse repetition rate of said bursts while maintaining the time between each burst and the immediately preceding range gate signal substantially constant.
 12. The method of claim 11 wherein said step of adjusting comprises varying the time between each range gate signal and the succeeding burst to be only above a determined minimum timing between said bursts and the following range gate signal.
 13. In the method of diagnostic analysis employing Doppler pulse generation comprising generating Doppler pulse drive signals in the form of bursts of a plurality of cycles each, applying aid drive signals to an ultrasound transducer for transmitting ultrasound, receiving echo ultrasound pulses responsive to said transmitted ultrasound via said transducer and applying them to a receiving means, generating a range gate signal, and displaying the output of said receiving means in response to said transmitted ultrasound bursts only during the occurrence of said range gate signal; the improvement comprising passing said received signals in said receiving means through a low pass filter, and adjusting the time between each said burst and the succeeding range gate signal and simultaneously adjusting the cut off frequency of said low pass filter whereby the cut off frequency is decreased as said time increases and the cutoff frequency is increased as said time decreases.
 14. In the method of diagnostic analysis employing Doppler generation comprising generating ultrasound drive signals, applying said drive signals to an ultrasound transducer for transmitting ultrasound, receiving echo ultrasound signals responsive to said transmitted ultrasound via said transducer and applying them to a receiving means, synchronously demodulating the received signals at 90 degrees to produce quadrature signals, and displaying the output of said receiving means during said range gate signal; the improvement comprising peak detecting said quadrature signals, level detecting the resultant peak detected signals to eliminate noise perturbations, generating pulse signals from said level detected signals in phase sensitive full wave pulse generating means and integrating the full wave generated signals to produce an output signal for diagnostic analysis.
 15. In a system for processing continuous signals where said sampling means are provided for sampling said signals at predetermined variable times following a reference time, the sampling means comprising means for producing a gate signal from a leading edge signal that has a timing that is variable with respect to said reference time, the improvement wherein said sampling means comprises means for establishing first and second clock signals of opposite phase for selectively initiating a range gate signal in response to the occurrence of said clock signals, said sampling means comprising means responsive to substantial coincidence between said leading edge and one of said first and second clock signals for initiating said range gate with the other of said clock signals.
 16. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and an ultrasound transducer connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses received in response to said emitted ultrasound pulses, the improvement wherein said transmitting means comprises means for generating a composite signal comprised of a train of single cycle pulse signals of substantially constant repetition rate each pulse of which is followed by a receiving period and interlaced with a train of Doppler pulse signals, said Doppler pulse signals each being comprised of a plurality of bursts each of a plurality of cycles followed by a receiving period, means for varying the repetition rate of said bursts, and means applying said composite signals as said drive signals to said transducer, and further comprising a narrow-band amplifier connected to said receiving means and means connecting said narrow-band amplifier to said transducer, said narrow-band amplifier having an input impedance critically tuned to reduce Johnson noise and thus provide a substantially improved signal-to-noise ratio at a predetermined frequency.
 17. The ultrasonic diagnostic apparatus of claim 16 wherein said connections means comprises a tuned matching transformer having a primary winding coupled to said transducer and a secondary winding coupled to said amplifier.
 18. The ultrasonic diagnostic apparatus of claim 17 wherein said transformer has a core that saturates when drive signals are applied to said transducer, the coupling between said primary and secondary windings being no greater than critical at the frequency of said drive signals.
 19. In an ultrasonic diagnostic apparatus including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, and an ultrasonic transducer connected to said transmitting means for emitting ultrasonic pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses received in response to said emitted ultrasound pulses, the improvement wherein said transmitting means comprises means for generating a composite signal comprised of a train of single cycle pulse signals of substantially constant repetition rate each pulse of which is followed by a receiving period and interlaced with a train of Doppler pulse signals, said Doppler pulse signals each being comprised of a plurality of bursts each of a plurality of cycles followed by a receiving period, means for varying the repetition rate of said bursts, and means applying said composite signals as said drive signals to said transducer, said receiving means comprising means for synchronously demodulating received signals to provide first and second signals demodulated at 90 degrees, means for peak detecting each of said first and second signals to produce peak detected signals, means for level detecting said peak detected signals, means for level detecting said peak detected signals to substantially eliminate noise perturbations therefrom, phase-sensitive full-wave pulse generating means connected to said level detecting means, and means for integrating the output of said pulse generating means for producing an output signal.
 20. In the method of diagnostic analysis comprising generating drive signals, applying said drive signals to an ultrasound transducer for transmitting ultrasound pulses, receiving echo ultrasound pulses responsive to said transmitted ultrasound pulses via said transducer and applying them to a receiving means, and displaying the output of said receiving means; the improvement wherein said step of generating drive signals comprises generating a composite drive signal comprised of a train of single cycle pulse signals of constant repetition rate each followed by a receive time and interlaced with a train of Doppler pulse signals, said Doppler pulse signals, each being comprised of a plurality of bursts of a plurality of cycles followed by a receive period, further comprising varying the repetition rate of said bursts, and said step of applying comprises applying said composite drive signal to said transducer, and further comprising the steps of synchronously demodulating received signals at 90 degrees to produce quadrature signals, peak detecting said quadrature signal level detecting the resultant peak detected signals to eliminate noise perturbations, generating pulse signals from said level detected signals in phase-sensitive full-wave pulse generating means, and integrating the generated pulse signals to produce an output signal.
 21. In an ultrasonic diagnostic apparatus, including transmitting means for generating drive signals, receiving means for producing output signals for diagnosis, and an ultrasound transducer connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses received in response to said emitted ultrasound pulses, the improvement wherein said receiving means comprises means for synchronously demodulating received signals to provide first and second signals demodulated at 90°, means for peak detecting each of said first and second signals to produce peak detected signals, means, and means or integrating the output of said pulse generating means for producing an output signal.
 22. In the method of diagnostic analysis comprising generating drive signals, applying said drive signals to an ultrasound transducer for transmitting ultrasound pulses, receiving echo ultrasound pulses responsive to said transmitted ultrasound pulses via said transducer and applying them to a receiving means, and displaying the output of said receiving means, the improvement comprising synchronously demodulating signals received by said receiving means at 90° to produce quadrature signal, peak detecting said quadrature signals, level detecting the resultant peak detected signals to eliminate noise perturbations, generating pulse signals from said level detected signals in phase-sensitive full-wave pulse generating means, and integrating the generated pulse signals to produce an output signal.
 23. In a ultrasonic diagnostic apparatus, including a transmitting means for generating drive signals, a receiving means for producing output signals for diagnosis, an ultrasound transducer means connected to said transmitting means for emitting ultrasound pulses in response to said drive signals and for applying signals to said receiving means in response to ultrasound pulses received in response to said emitted ultrasound pulses, the improvement wherein said transmitting means comprises means for generating a train of Doppler pulse signals, each comprised of a burst of plurality of cycles followed by a receiving cycle, and means for generating a range gate signal for applying gate signals to said receiving means to enable reception of signals by said receiving means corresponding to said Doppler pulse signals only during predetermined periods following each Doppler pulse signal, means for applying said Doppler signals to said transducer means as said drive signals, and means for adjusting the time between each Doppler pulse signal and the respective range gate signal, said means for generating a range gate signal comprising means for establishing first and second clock signals of opposite phase, and means responsive to substantial coincidence between the leading edge of said range gate signal and one of said first and second clock signals for initiating said range gate signal with the other of said clock signals, aid one clock signal being that one of said clock signals that initiated the last previous range gate signal. 